| Election Name: | 1944 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1938 United States Senate election in Missouri |
| Previous Year: | 1938 |
| Next Election: | 1950 United States Senate election in Missouri |
| Next Year: | 1950 |
| Image1: | Forrest C. Donnell.jpg |
| Nominee1: | Forrest C. Donnell |
| Party1: | Republican Party (US) |
| Popular Vote1: | 778,778 |
| Percentage1: | 49.95% |
| Nominee2: | Roy McKittrick |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 776,790 |
| Percentage2: | 49.82% |
| Map Size: | 270px |
| U.S. senator | |
| Before Election: | Bennett Champ Clark |
| Before Party: | Democratic Party (US) |
| After Election: | Forrest C. Donnell |
| After Party: | Republican Party (US) |
The 1944 United States Senate election in Missouri took place on November 7, 1944 in Missouri. Incumbent Democratic Senator Bennett Champ Clark was defeated in the primary by Roy McKittrick, who went on to lose the general election to Republican nominee Forrest C. Donnell. Donnell outperformed presidential candidate Thomas E. Dewey, who lost the state with 48.4% of the vote in the presidential election.