| Club: | Puebla |
| Season: | 1944-45 |
| Chairman: | Joaquín Diaz Loredo |
| Manager: | Eduardo Morilla |
| Stadium: | El Mirador |
| League: | 1944–45 Mexican Primera División season |
| League Result: | 2nd |
| Cup1: | Apertura 2017 Copa MX |
| Pattern B1: | _Pueblafc13 |
| Leftarm1: | FFFFFF |
| Body1: | 000040 |
| Rightarm1: | FFFFFF |
| Shorts1: | 0000FF |
| Socks1: | 0000FF |
| Pattern B2: | _VisitaPue2 |
| Leftarm2: | 0000FF |
| Body2: | 0000FF |
| Rightarm2: | 0000FF |
| Shorts2: | FFFFFF |
| Socks2: | 0000FF |
| Nextseason: | 1945-1946 |
The 1944–45 Puebla season was the first professional season of Mexico's top-flight football league. This was the first season the club played in the Mexican professional league. The club had joined a year after the league began competition in 1943. Puebla finished second in the league to Club Espana and managed to establishment itself as one of the countries powerful clubs.
1944-45 season was the first the club played in the First Division after being invited by the league in 1943.
Puebla Had by weeks in rounds 3 and 4th .
First leg:
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|---|---|---|---|---|---|---|
| June 3, 1945 | ||||||
| Atlas | 4-4 | Puebla | ||||
| Asturias | 4-3 | Oro | ||||
| Moctezuma | 1-3 | América | ||||
Second leg:
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|---|---|---|---|---|---|---|
| June 10, 1945 | ||||||
| Puebla | 4-0 | Atlas | agg: 8-4 | |||
| Oro | 5-3 | Asturias | agg: 8-7 | |||
| América | 2-3 | Moctezuma | agg: 5-4 | |||
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|---|---|---|---|---|---|---|
| June 17, 1945 | ||||||
| Puebla | 3-1 | Oro |
América bye to Final
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|---|---|---|---|---|---|---|
| June 24, 1945 | ||||||
| América | 4-6 | Puebla |
| No. | Pos. | Nation | Name | Liga | Cup | Total | |
|---|---|---|---|---|---|---|---|
| FW |  | Ricardo Alarcón | 12 | 4 | 16 | ||
| FW | | Guadalupe Velásquez | 12 | 2 | 14 | ||
| FW |  | Walter Meneses | 8 | 8 | |||
| MF | | Manuel Alonso | 4 | 4 | |||
| MF | | Arturo Chavez | 4 | 15 | 19 | ||
| FW |  | Eladio Vaschetto | 4 | 3 | 7 | ||
| FW | | Bruno Rodolfi | 2 | 2 | |||
| FW | | Juan José González | 2 | 2 | |||
| DF | | Rafael Escalada | 1 | 1 | |||
| DF | | Alfonso Escobedo | 1 | 1 | |||
| DF | | Miguel López | 1 | 1 | |||
| DF | | Filiberto Guerrero | 1 | 2 | 3 |