| Competition: | League of Ireland |
| Season: | 1944–45 |
| Winners: | Cork United (4th title) |
| League Topscorer: | Seán McCarthy (26 goals) |
| Biggest Home Win: | Limerick 9–1 Dundalk |
| Biggest Away Win: | Brideville 0–9 Cork United |
| Highest Scoring: | Brideville 4–7 Drumcondra |
| Matches: | 56 |
| Total Goals: | 229 |
| Prevseason: | 1943–44 |
| Nextseason: | 1945–46 |
The 1944–45 League of Ireland was the 24th season of senior football in the Republic of Ireland. Shelbourne were the defending champions.
St James's Gate failed to be re-elected and were replaced by Brideville, who returned after a one-year absence.
| Team | Location | Stadium | |
|---|---|---|---|
| Bohemians | Dublin (Phibsborough) | Dalymount Park | |
| Brideville | Dublin (The Liberties) | Harold's Cross Stadium | |
| Cork United | Cork | Mardyke | |
| Drumcondra | Dublin (Clonturk) | Clonturk Park | |
| Dundalk | Dundalk | Oriel Park | |
| Limerick | Limerick | Markets Field | |
| Shamrock Rovers | Dublin (Milltown) | Glenmalure Park | |
| Shelbourne | Dublin (Ringsend) | Shelbourne Park |
Cork United won their fourth title in five years.