| Year: | 1943 |
| Team: | Saint Mary's Pre-Flight Air Devils |
| Sport: | football |
| Conference: | Independent |
| Record: | 3–4–1 |
| Head Coach: | Spike Nelson |
| Hc Year: | 1st |
| Stadium: | Kezar Stadium |
The 1943 Saint Mary's Pre-Flight Air Devils football team was an American football team that represented the United States Navy pre-flight school at Saint Mary's College of California during the 1943 college football season. The team compiled a 3–4–1 record. Spike Nelson was the head coach. The team included 1941 Heisman Trophy winner Bruce Smith.
In the final Litkenhous Ratings, Saint Mary's Pre-Flight ranked 32nd among the nation's college and service teams with a rating of 90.5.[1]