| Season: | 1943 |
| Manager: | Conrad Ross Joreca |
| Mgrtitle: | Manager |
| Chairman: |  Décio Pacheco Pedroso |
| Chrtitle: | Chairman |
| League: | Torneio Rio-São Paulo |
| Cup1: | Campeonato Paulista |
| Cup1 Result: | Champions |
| Prevseason: | 1942 |
| Nextseason: | 1944 |
The 1943 football season was São Paulo's 14th season since the club's founding in 1930.
| Games played | 43 (20 Campeonato Paulista, 23 Friendly match) |
| Games won | 31 (15 Campeonato Paulista, 16 Friendly match) |
| Games drawn | 7 (3 Campeonato Paulista, 4 Friendly match) |
| Games lost | 5 (2 Campeonato Paulista, 3 Friendly match) |
| Goals scored | 136 |
| Goals conceded | 44 |
| Goal difference | +92 |
| Best result | 10–0 (A) v Olímpico - Friendly match - 1943.11.14 |
| Worst result | 1–3 (A) v Fluminense - Friendly match - 1943.04.21 |
| Most appearances | |
| Top scorer | |