| Year: | 1943 |
| Team: | Oklahoma Sooners |
| Sport: | football |
| Conference: | Big Six Conference |
| Short Conf: | Big 6 |
| Record: | 7–2 |
| Conf Record: | 5–0 |
| Head Coach: | Dewey Luster |
| Hc Year: | 3rd |
| Captain: | Bob Brumley |
| Captain2: | W. G. Wooten |
| Champion: | Big 6 champion |
The 1943 Oklahoma Sooners football team represented the University of Oklahoma in the 1943 college football season. In their third year under head coach Dewey Luster, the Sooners compiled a 7–2 record (5–0 against conference opponents), won the Big Six Conference championship, and outscored their opponents by a combined total of 187 to 92.[1] [2]
No Sooners received All-America honors in 1943,[3] but six Sooners received all-conference honors: Bob Brumley (back), Gale Fulgham (guard), Lee Kennon (tackle), W.G. Lamb (end), Derald Lebow (back), and Bob Mayfield (center).[4]
In the final Litkenhous Ratings, Oklahoma ranked 41st among the nation's college and service teams with a rating of 85.7.[5]
The following players were drafted into the National Football League following the season.[7]
| 12 | 111 | Jim Tyree | End | Brooklyn Tigers | |
| 22 | 227 | Ed Davis | Guard | Chicago Bears | |
| 22 | 230 | Clare Morford | Back | Boston Yanks | |
| 23 | 233 | Max Fischer | Center | Detroit Lions | |
| 27 | 276 | Joe Golding | Back | Brooklyn Tigers |