| Year: | 1943 |
| Team: | Lafayette Leopards |
| Sport: | football |
| Conference: | Middle Three Conference |
| Short Conf: | Middle Three |
| Record: | 4–1 |
| Conf Record: | 3–1 |
| Head Coach: | Ben Wolfson |
| Hc Year: | 1st |
| Captain: | Walter Sergy |
| Stadium: | Fisher Field |
| Champion: | Middle Three co-champion |
The 1943 Lafayette Leopards football team was an American football team that represented Lafayette College in the Middle Three Conference during the 1943 college football season. In its first season under head coach Ben Wolfson, the team compiled a 4–1 record and won the Middle Three championship.[1] Walter Sergy was the team captain.[2] The team played home games at Fisher Field in Easton, Pennsylvania.
In the final Litkenhous Ratings, Lafayette ranked 111th among the nation's college and service teams with a rating of 63.6.[3]