| Election Name: | 1942 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1936 United States Senate election in Wyoming |
| Previous Year: | 1936 |
| Next Election: | 1948 United States Senate election in Wyoming |
| Next Year: | 1948 |
| Election Date: | November 3, 1942 |
| Image1: | Edward V Robertson.jpg |
| Nominee1: | Edward V. Robertson |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 41,486 |
| Percentage1: | 54.59% |
| Nominee2: | Harry Schwartz |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 34,503 |
| Percentage2: | 45.41% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | Harry Schwartz |
| Before Party: | Democratic Party (United States) |
| After Election: | Edward V. Robertson |
| After Party: | Republican Party (United States) |
The 1942 United States Senate election in Wyoming was held on November 3, 1942. Democratic Senator Harry Schwartz ran for re-election to his second term. He was challenged by businessman Edward V. Robertson, who emerged from a close and hotly contested Republican primary as the narrow winner. Aided in part by the national swing toward Republicans in 1942, Robertson defeated Schwartz for re-election by a decisive margin.