| Election Name: | 1942 United States Senate election in Oklahoma |
| Country: | Oklahoma |
| Flag Image: | Flag of Oklahoma (1941–1988).svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1936 United States Senate election in Oklahoma |
| Previous Year: | 1936 |
| Next Election: | 1948 United States Senate election in Oklahoma |
| Next Year: | 1948 |
| Election Date: | November 3, 1942 |
| Image1: | File:Edward Hall Moore.jpg |
| Nominee1: | Edward H. Moore |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 204,163 |
| Percentage1: | 54.83% |
| Nominee2: | Joshua B. Lee |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 166,653 |
| Percentage2: | 44.76% |
| U.S. Senator | |
| Before Election: | Joshua B. Lee |
| Before Party: | Democratic Party (United States) |
| After Election: | Edward H. Moore |
| After Party: | Republican Party (United States) |
The 1942 United States Senate election in Oklahoma took place on November 3, 1942. Incumbent Democratic Senator Joshua B. Lee ran for re-election to a second consecutive term. After winning the Democratic primary against several strong opponents, Lee advanced to the general election, where he was originally set to face former Republican Senator William B. Pine. However, shortly after winning the Republican primary, Pine died; the state Republican Party tapped businessman Edward H. Moore as its replacement nominee. In a favorable Republican environment, Moore defeated Lee by a wide margin to win his first and only term in the U.S. Senate.
After he won the Republican primary, William B. Pine died, leaving a vacancy on the Republican ticket.[3] The Republican Party selected wealthy businessman Edward H. Moore as its replacement nominee.[4]