| Election Name: | 1942 United States Senate election in Minnesota |
| Country: | Minnesota |
| Flag Year: | 1893 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1942 United States Senate special election in Minnesota |
| Previous Year: | 1942 (special) |
| Next Election: | 1948 United States Senate election in Minnesota |
| Next Year: | 1948 |
| Election Date: | November 3, 1942 |
| Image1: | JosephBall.jpg |
| Nominee1: | Joseph H. Ball |
| Party1: | Republican Party (Minnesota) |
| Popular Vote1: | 356,297 |
| Percentage1: | 46.98% |
| Party2: | Minnesota Farmer–Labor Party |
| Popular Vote2: | 213,965 |
| Percentage2: | 28.21% |
| Image4: | Martin A. Nelson.png |
| Party4: | Independent (US) |
| Popular Vote4: | 109,226 |
| Percentage4: | 14.40% |
| Image5: | Ed Murphy 1940.jpg |
| Nominee5: | Ed Murphy |
| Party5: | Democratic Party of Minnesota |
| Popular Vote5: | 78,959 |
| Percentage5: | 10.41% |
| Map Size: | 270px |
| U.S. Senator | |
| Before Party: | Republican Party (Minnesota) |
| After Party: | Republican Party (Minnesota) |
The 1942 United States Senate election in Minnesota took place on November 3, 1942. Incumbent Republican Joseph H. Ball, who had been temporarily appointed by Governor Harold Stassen in 1940 to fill the seat of the deceased Farmer–Labor U.S. Senator Ernest Lundeen, defeated Farmer–Labor former U.S. Senator and former Governor Elmer Benson, independent candidate Martin A. Nelson, and Democratic nominee Ed Murphy, to win election to the full six-year term beginning in January 1943. A special election held on the same date elected Republican nominee Arthur E. Nelson to serve the remainder of Lundeen's unexpired term.
Following his 1940 appointment and subsequent election, Ball ultimately served the longest tenure of any Senator only elected once.