| Election Name: | 1942 United States Senate election in Michigan |
| Country: | Michigan |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1936 United States Senate election in Michigan |
| Previous Year: | 1936 |
| Next Election: | 1948 United States Senate election in Michigan |
| Next Year: | 1948 |
| Election Date: | November 2, 1942 |
| Image1: | File:Homer S. Ferguson 1949.png |
| Nominee1: | Homer S. Ferguson |
| Party1: | Republican Party (US) |
| Popular Vote1: | 589,652 |
| Percentage1: | 49.55% |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 561,595 |
| Percentage2: | 47.20% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Party: | Democratic Party (US) |
| After Party: | Republican Party (US) |
The 1942 United States Senate election in Michigan was held on November 2, 1942. Incumbent Democratic U.S. Senator Prentiss M. Brown ran for re-election to second term in office, but was defeated by Republican Homer S. Ferguson.