| Election Name: | 1942 United States Senate election in Iowa |
| Country: | Iowa |
| Flag Image: | Flag of Iowa (xrmap collection).svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1936 United States Senate election in Iowa |
| Previous Year: | 1936 |
| Next Election: | 1948 United States Senate election in Iowa |
| Next Year: | 1948 |
| Election Date: | November 3, 1942 |
| Nominee1: | George A. Wilson |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 410,383 |
| Percentage1: | 57.98% |
| Nominee2: | Clyde Herring |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 295,194 |
| Percentage2: | 41.70% |
| Map Size: | 220px |
| U.S. Senator | |
| Before Election: | Clyde Herring |
| Before Party: | Democratic Party (United States) |
| After Election: | George A. Wilson |
| After Party: | Republican Party (United States) |
The 1942 United States Senate election in Iowa took place on November 3, 1942. Incumbent Democratic Senator Clyde Herring ran for re-election to a second term but was defeated by Republican Governor George A. Wilson.
After losing the primary, Seemann entered the general election on the "Progressive New Dealer" ticket.