| Year: | 1942 |
| Team: | Saint Louis Billikens |
| Sport: | football |
| Conference: | Missouri Valley Conference |
| Short Conf: | MVC |
| Record: | 4–5 |
| Conf Record: | 2–3 |
| Head Coach: | Dukes Duford |
| Hc Year: | 3rd |
| Stadium: | Edward J. Walsh Memorial Stadium |
| Next Year: | 1945 |
The 1942 Saint Louis Billikens football team was an American football team that represented Saint Louis University as a member of the Missouri Valley Conference (MVC) during the 1942 college football season. In its third season under head coach Dukes Duford, the team compiled a 4–5 record and was outscored by a total of 215 to 110.[1]
Saint Louis was ranked at No. 154 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.[2]
The team played its home games at Edward J. Walsh Memorial Stadium in St. Louis.