| Year: | 1942 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Independent |
| Record: | 4–0 |
| Head Coach: | Reed Green |
| Hc Year: | 6th |
| Stadium: | Faulkner Field |
| Next: | 1946 |
The 1942 Mississippi Southern Southerners football team represented Mississippi Southern College (now known as the University of Southern Mississippi) in the 1942 college football season. The team compiled a 4–0 record in the wartime football setting of WWII, and outscored their opponents by a total of 142 to 7.