| Year: | 1942 |
| Team: | Memphis State Tigers |
| Sport: | football |
| Conference: | Independent |
| Record: | 2–7 |
| Head Coach: | Lefty Jamerson |
| Hc Year: | 1st |
| Captain: | Preston Watts, Frank Simmons |
| Stadium: | Crump Stadium |
| Next Year: | 1947 |
The 1942 Memphis State Tigers football team was an American football team that represented Memphis State College (now known as the University of Memphis) as an independent during the 1942 college football season. In their first season and season under head coach Lefty Jamerson, the Tigers compiled a 2–7 record.
Memphis State was ranked at No. 360 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.[1]