| Competition: | Serie B |
| Season: | 1942–43 |
| Winners: | Modena 1st title |
| Prevseason: | 1941–42 |
| Nextseason: | 1945–46 North → 1945–46 South |
The Serie B 1942–43 was the fourteenth tournament of this competition played in Italy since its creation.
Cremonese, Anconitana, M.A.T.E.R. and Palermo had been promoted from Serie C, while Napoli and Modena had been relegated from Serie A.
Goal average was abolished.
This was the last championship before a two-years break due to World War II.