| Competition: | Serie A |
| Season: | 1942–43 |
| Winners: | Torino 2nd title |
| League Topscorer: | Silvio Piola (21 goals) |
| Matches: | 240 |
| Total Goals: | 742 |
| Prevseason: | 1941–42 |
| Nextseason: | 1945–46 |
The 1942–43 Serie A season was won by Torino.
Bari and Vicenza had been promoted from Serie B.
Goal average was abolished.
This was the last championship before a two-years break due to World War II.
Played in Rome, Florence and Modena.Triestina remained in Serie A. A second round was needed and played in Bologna.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Silvio Piola | Lazio | 21 |
| 2 | Guglielmo Trevisan | Genova 1893 | 19 |
| 3 | Vittorio Sentimenti | Juventus | 17 |
| 4 |  Riza Lushta | Juventus | 16 |
| 5 | Roma | 14 | |
| Guglielmo Gabetto | Torino | ||
| Giovanni Gaddoni | Ambrosiana-Inter | ||
| 8 | Frane Matošić | Bologna | 13 |
| 9 | Torino | 12 | |
| Adriano Gè | Atalanta | ||
| Alberto Marchetti | Vicenza | ||
| Teresio Piana | Livorno |