| Competition: | Segunda División |
| Season: | 1942–43 |
| Winners: | Sabadell |
| Promoted: | Sabadell Real Sociedad |
| Relegated: | Tarrasa Málaga Ferrol Gerona Elche Real Santander Ferroviaria Cádiz Salamanca Alavés |
| League Topscorer: | José Saras (14 goals) |
| Best Goalkeeper: | Andrés Company (0.79 goals/match) |
| Biggest Home Win: | (4 October 1942) (11 October 1942) (11 October 1942) (8 November 1942) |
| Biggest Away Win: | (18 October 1942) |
| Highest Scoring: | (11 October 1942) |
| Matches: | 168 |
| Total Goals: | 586 |
| Prevseason: | 1941–42 |
| Nextseason: | 1943–44 |
24 teams joined the league, including two relegated from the 1941–42 La Liga and 3 promoted from Divisiones Regionales.
| Club | City | Stadium | |
|---|---|---|---|
| Arenas Club | Guecho | Ibaiondo | |
| Baracaldo | Baracaldo | Lasesarre | |
| Cultural y Deportiva Leonesa | León | La Corredera | |
| Club Ferrol | Ferrol | Inferniño | |
| Real Gijón | Gijón | El Molinón | |
| UD Salamanca | Salamanca | El Calvario | |
| Real Santander SD | Santander | El Sardinero | |
| Real Valladolid Deportivo | Valladolid | José Zorrilla |
| Goalscorers | Goals | Team |
|---|---|---|
 José Saras | 14 | Real Santander |
| Pruden | 11 | Salamanca |
| Chipía | 10 | Real Gijón |
| 10 | Valladolid | |
| Constante Carnero | 10 | Ferrol |
| Goalkeeper | Goals | Matches | Average | Team | |
|---|---|---|---|---|---|
| José Luis Izpizua | 17 | 14 | Valladolid | ||
| José Antonio Barrie | 16 | 11 | Arenas | ||
| Gregorio Leicea | 23 | 14 | Real Gijón | ||
| Fernando Llorente | 30 | 14 | Baracaldo | ||
| Moreno | 33 | 14 | Ferrol |
| Club | City | Stadium | |
|---|---|---|---|
| Deportivo Alavés | Vitoria | Mendizorroza | |
| CD Constancia | Inca | Camp d’Es Cos | |
| AD Ferroviaria | Madrid | Campo de Delicias | |
| Gerona CF | Gerona | Vista Alegre | |
| CA Osasuna | Pamplona | San Juan | |
| Real Sociedad | San Sebastián | Atocha | |
| CD Sabadell FC | Sabadell | Cruz Alta | |
| CD Tarrasa | Tarrasa | Pi i Margall |
| Goalscorers | Goals | Team |
|---|---|---|
| Sebastián Ontoria | 13 | Real Sociedad |
| Vicente Unamuno | 13 | Real Sociedad |
| Pedrín | 8 | Real Sociedad |
| 8 | Osasuna | |
| Blai | 8 | Tarrasa |
| Goalkeeper | Goals | Matches | Average | Team | |
|---|---|---|---|---|---|
| Andrés Company | 11 | 14 | Constancia | ||
| Eduardo Chillida | 11 | 11 | Real Sociedad | ||
| José Francàs | 24 | 14 | Gerona | ||
| Ricardo Pujol | 19 | 11 | Sabadell | ||
| Miguel Bermejo | 21 | 12 | Ferroviaria |
| Goalscorers | Goals | Team |
|---|---|---|
| Vicente Morera | 8 | Jerez |
| Marcelino Morla | 7 | Ceuta |
| Juan Trujillo | 7 | Murcia |
| 7 | Alcoyano | |
| José Corona | 6 | Hércules |
| Goalkeeper | Goals | Matches | Average | Team | |
|---|---|---|---|---|---|
| Pedrín | 10 | 11 | Murcia | ||
| Joaquín Comas | 17 | 14 | Ceuta | ||
| Juan Betancor | 18 | 14 | Hércules | ||
| Antonio García | 15 | 10 | Cádiz | ||
| José Bañón | 22 | 14 | Elche |