| Competition: | Primeira Liga |
| Season: | 1942–43 |
| Winners: | Benfica 5th title |
| Matches: | 90 |
| Total Goals: | 539 |
| Prevseason: | 1941–42 |
| Nextseason: | 1943–44 |
The 1942–43 Primeira Divisão was the ninth season of top-tier football in Portugal.
It was contested by 10 teams, and S.L. Benfica won the championship.