| Competition: | Nationalliga |
| Season: | 1942–43 |
| Winners: | Grasshopper (12th title) |
| Relegated: | Nordstern Basel |
| League Topscorer: | Lauro Amadò (31) |
| Dates: | 6 September 1942 – 20 June 1943 |
| Matches: | 182 |
| Total Goals: | 630 |
| Prevseason: | 1941–42 |
| Nextseason: | 1943–44 |
Statistics of Swiss Super League in the 1942–43 season.
It was contested by 14 teams, and Grasshopper Club Zürich won the championship.