| Mode: | Basketball |
| Year: | 1942–43 |
| Prev Year: | 1941–42 |
| Next Year: | 1943–44 |
| Team: | DePaul Blue Demons |
| Conference: | Independent |
| Record: | 19–5 |
| Hc Year: | 1st |
| Tourney Result: | Final Four |
The 1942–43 DePaul Blue Demons men's basketball team represented DePaul University during the 1942–43 NCAA men's basketball season. They were led by head coach Ray Meyer, in the first season of his legendary career, and played their home games at the University Auditorium in Chicago. The Blue Demons were one of eight teams invited to take part in the NCAA tournament. DePaul defeated Dartmouth, a team that reached the Final Four the season before, before losing to Georgetown in the National semifinal round. They finished the season with an overall record of 19–5.
|-!colspan=12 style=| Regular season
|-!colspan=12 style=| NCAA Tournament[1]