| Election Name: | 1941 United States Senate special election in Mississippi |
| Country: | Texas |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1936 United States Senate election in Mississippi |
| Previous Year: | 1936 |
| Next Election: | 1942 United States Senate election in Mississippi |
| Next Year: | 1942 |
| Election Date: | September 29, 1941 |
| Image1: | File:DOXEY, WALL. HONORABLE. PORTRAIT LCCN2016870528 (cropped).jpg |
| Nominee1: | Wall Doxey |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 59,556 |
| Percentage1: | 50.35% |
| Nominee2: | Ross A. Collins |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 58,738 |
| Percentage2: | 49.65% |
| U.S. Senator | |
| Before Election: | Wall Doxey |
| Before Party: | Democratic Party (United States) |
| After Election: | James Eastland |
| After Party: | Democratic Party (United States) |
The 1941 United States Senate special election in Mississippi was held on September 29 to complete the unexpired term of Senator Pat Harrison. Interim Senator James Eastland did not run for a full term in office. In the election, U.S. Representative Wall Doxey narrowly defeated his House colleague Ross A. Collins.
Four-term Democratic senator Pat Harrison died June 22, 1941. Governor Paul B. Johnson Sr. appointed Democratic planter and former state representative James Eastland on June 30 to fill the vacant seat until a successor could be duly elected. Eastland was appointed after his father, Woods Eastland, declined and on the condition that he would not run in the special election to complete the term.
In the 1942 election for a full term, James Eastland ran and defeated both Doxey and Collins.