| Year: | 1941 |
| Team: | USC Trojans |
| Sport: | football |
| Conference: | Pacific Coast Conference |
| Short Conf: | PCC |
| Record: | 2–6–1 |
| Conf Record: | 2–4–1 |
| Head Coach: | Sam Barry |
| Hc Year: | 1st |
| Stadium: | Los Angeles Memorial Coliseum |
The 1941 USC Trojans football team was an American football team that represented the University of Southern California as a member of the Pacific Coast Conference during the 1941 college football season. The team was led by first-year head coach Sam Barry who took over after Howard Jones died during the previous off-season. Barry also coached USC's basketball and baseball teams. The Trojans compiled a 2–6–1 record (2–4–1 against PCC opponents) and finished eighth out of ten in the conference.[1]
USC was ranked at No. 64 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System for 1941.[2]