| Year: | 1941 |
| Team: | Saint Louis Billikens |
| Sport: | football |
| Conference: | Missouri Valley Conference |
| Short Conf: | MVC |
| Record: | 4–5–1 |
| Conf Record: | 1–3–1 |
| Head Coach: | Dukes Duford |
| Hc Year: | 2nd |
| Stadium: | Walsh Stadium |
The 1941 Saint Louis Billikens football team was an American football team that represented Saint Louis University as a member of the Missouri Valley Conference (MVC) during the 1941 college football season. In its second season under head coach Dukes Duford, the team compiled a 4–5–1 record (1–3–1 against MVC opponents), finished fourth in the conference, and was outscored by a total of 150 to 100.[1] The team played its home games at Walsh Stadium in St. Louis.
Quarterback Dick Weber was selected by the conference coaches as a first-team player on the 1941 All-Missouri Valley Conference football team.[2]
Saint Louis was ranked at No. 143 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System for 1941.[3]