| Competition: | Segunda División |
| Season: | 1941–42 |
| Winners: | Real Betis |
| Promoted: | Real Betis Real Zaragoza |
| Relegated: | Real Unión Levante-Gimnástico Cartagena CF |
| League Topscorer: | José Mijares (18 goals) |
| Best Goalkeeper: | Ricardo Pujol (0.81 goals/match) |
| Biggest Home Win: | (19 October 1941) (2 November 1941) (16 November 1941) |
| Biggest Away Win: | (26 October 1941) |
| Highest Scoring: | (9 November 1941) |
| Matches: | 168 |
| Total Goals: | 655 |
| Prevseason: | 1940–41 |
| Nextseason: | 1942–43 |
The 1941–42 Segunda División season saw 24 teams participate in the second flight Spanish league. Betis and Zaragoza was promoted to Primera División. Real Unión, Levante and Cartagena were relegated to Divisiones Regionales de Fútbol.
24 teams joined the league, including two relegated from the 1940–41 La Liga and 5 promoted from Divisiones Regionales.
| Goalscorers | Goals | Team |
|---|---|---|
 José Mijares | 18 | Real Gijón |
| Pruden | 16 | Salamanca |
| Portugués | 12 | Ferrol |
| 12 | Valladolid | |
| Martín Aroma | 9 | Arenas |
| Goalkeeper | Goals | Matches | Average | Team | |
|---|---|---|---|---|---|
| Moreno | 16 | 12 | Ferrol | ||
| Manuel Joven | 19 | 12 | Salamanca | ||
| Pablito | 19 | 11 | Real Gijón | ||
| Joaquín Caller | 24 | 13 | Real Santander | ||
| José María Busto | 24 | 12 | Baracaldo |
| Club | City | Stadium | |
|---|---|---|---|
| Deportivo Alavés | Vitoria | Mendizorroza | |
| CD Constancia | Inca | Camp d’Es Cos | |
| AD Ferroviaria | Madrid | Campo de Delicias | |
| Gerona CF | Gerona | Vista Alegre | |
| UD Levante-Gimnástico | Valencia | Vallejo | |
| CA Osasuna | Pamplona | San Juan | |
| Real Sociedad | San Sebastián | Atocha | |
| CD Sabadell FC | Sabadell | Cruz Alta |
| Goalscorers | Goals | Team |
|---|---|---|
| Carlos Sanz | 16 | Constancia |
| Miguel Gual | 12 | Sabadell |
| Vicente Martínez | 10 | Zaragoza |
| 9 | Alavés | |
| Florentino Zubizarreta | 7 | Alavés |
| Goalkeeper | Goals | Matches | Average | Team | |
|---|---|---|---|---|---|
| Ricardo Pujol | 9 | 11 | Sabadell | ||
| Andrés Company | 18 | 14 | Constancia | ||
| José Francàs | 20 | 14 | Gerona | ||
| Jesús Ederra | 18 | 11 | Osasuna | ||
| José Valero | 20 | 12 | Zaragoza |
| Goalscorers | Goals | Team | |
|---|---|---|---|
| José Vilanova | 14 | Murcia | |
| Paquirri | 13 | Real Betis | |
| Saro | 10 | Real Betis | |
| 9 | Ceuta | ||
| Manuel Olivares | 8 | CD Málaga |
| Goalkeeper | Goals | Matches | Average | Team | |
|---|---|---|---|---|---|
| Joaquín Comas | 12 | 12 | Ceuta | ||
| Ramón Mendaro | 21 | 14 | CD Málaga | ||
| Francisco Suárez | 19 | 12 | Murcia | ||
| Paquillo | 21 | 13 | Real Betis | ||
| Francisco Larios | 27 | 11 | Xerez Club |