| Election Name: | 1940 United States Senate election in Ohio |
| Country: | Ohio |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1934 United States Senate election in Ohio |
| Previous Year: | 1934 |
| Next Election: | 1946 United States Senate election in Ohio |
| Next Year: | 1946 |
| Election Date: | November 5, 1940 |
| Image1: | File:Harold Hitz Burton 1921.jpg |
| Nominee1: | Harold Burton |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,602,498 |
| Percentage1: | 52.37% |
| Nominee2: | John McSweeney |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 1,457,304 |
| Percentage2: | 47.63% |
| Map Size: | 200px |
| U.S. Senator | |
| Before Election: | Vic Donahey |
| Before Party: | Democratic Party (United States) |
| After Election: | Harold Hitz Burton |
| After Party: | Republican Party (United States) |
The 1940 United States Senate election in Ohio took place on November 5, 1940. Incumbent Democratic Senator Vic Donahey did not run for re-election to a second term. In the open race to succeed him, Republican Mayor of Cleveland Harold Hitz Burton defeated Democratic U.S. Representative John McSweeney.