| Election Name: | 1938 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1932 United States Senate election in Missouri |
| Previous Year: | 1932 |
| Next Election: | 1944 United States Senate election in Missouri |
| Next Year: | 1944 |
| Image1: | Bennet Champ Clark.jpg |
| Nominee1: | Bennett Champ Clark |
| Party1: | Democratic Party (US) |
| Popular Vote1: | 757,587 |
| Percentage1: | 60.69% |
| Nominee2: | Henry S. Caulfield |
| Party2: | Republican Party (US) |
| Popular Vote2: | 488,687 |
| Percentage2: | 39.15% |
| Map Size: | 270px |
| U.S. senator | |
| Before Election: | Bennett Champ Clark |
| Before Party: | Democratic Party (US) |
| After Election: | Bennett Champ Clark |
| After Party: | Democratic Party (US) |
The 1938 United States Senate election in Missouri took place on November 8, 1938 in Missouri. The incumbent Democratic Senator, Bennett Champ Clark, was re-elected with 60.69% of the vote. He defeated Republican candidate and former Governor of Missouri Henry S. Caulfield.