| National Challenge Cup | |
| Year: | 1935 |
| Country: |  United States |
| Dates: | 13 January- 12 May 1935 |
| Defending Champions: | Stix, Baer and Fuller |
| Winners: | St. Louis Central Breweries |
| Count: | 3 |
| Second: | Pawtucket Rangers |
| Semifinal1: | Wieboldt Wonderbolts |
| Semifinal2: | Scots Americans |
| Prev Season: | 1934 |
| Next Season: | 1936 |
The 1935 National Challenge Cup was the annual open cup held by the United States Football Association now known as the Lamar Hunt U.S. Open Cup.
a)aggregate after 5 games, Central advances on 2 wins to Wieboldt's 1