| Election Name: | 1932 United States Senate election in Indiana |
| Country: | Indiana |
| Type: | Presidential |
| Ongoing: | no |
| Previous Election: | 1926 United States Senate election in Indiana |
| Previous Year: | 1926 |
| Next Election: | 1938 United States Senate election in Indiana |
| Next Year: | 1938 |
| Election Date: | November 8, 1932 |
| Nominee1: | Frederick Van Nuys |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 870,053 |
| Percentage1: | 55.57% |
| Nominee2: | James E. Watson |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 661,750 |
| Percentage2: | 42.26% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | James E. Watson |
| Before Party: | Republican Party (United States) |
| After Election: | Frederick Van Nuys |
| After Party: | Democratic Party (United States) |
The 1932 United States Senate election in Indiana took place on November 8, 1932. Incumbent Republican Senator and Senate Majority Leader James E. Watson ran for a third term in office, but was defeated by Frederick Van Nuys in a landslide.
This marked the first time in history that a Senate leader lost re-election, and the only time they were a Republican.