| Election Name: | 1928 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1922 United States Senate election in Wyoming |
| Previous Year: | 1922 |
| Next Election: | 1934 United States Senate election in Wyoming |
| Next Year: | 1934 |
| Election Date: | November 6, 1928 |
| Image1: | File:KENDRICK, JOHN B. GOVERNOR LCCN2016859134 (cropped).jpg |
| Nominee1: | John B. Kendrick |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 43,032 |
| Percentage1: | 53.50% |
| Nominee2: | Charles E. Winter |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 37,076 |
| Percentage2: | 46.09% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | John B. Kendrick |
| Before Party: | Democratic Party (United States) |
| After Election: | John B. Kendrick |
| After Party: | Democratic Party (United States) |
The 1928 United States Senate election in Wyoming took place on November 6, 1928. Democratic Senator John B. Kendrick ran for re-election to a third term. He faced Republican Congressman Charles E. Winter in the general election, and a competitive general election ensued. Kendrick ended up winning re-election by a narrow margin, with Winters's campaign likely assisted by the strong performance of Herbert Hoover in that year's presidential election. Kendrick's third term would turn out to be his last; he died while in office on November 3, 1933, about a year until the seat would next be up. Joseph C. O'Mahoney was appointed to serve out the remainder of Kendrick's term and would end up winning the ensuing election in 1934.