| Election Name: | 1928 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1922 United States Senate election in Missouri |
| Previous Year: | 1922 |
| Next Election: | 1934 United States Senate election in Missouri |
| Next Year: | 1934 |
| Election Date: | November 6, 1928 |
| Image1: | PATTERSON, ROSCOE. SENATOR LCCN2016861077 (cropped).jpg |
| Nominee1: | Roscoe C. Patterson |
| Party1: | Republican Party (US) |
| Popular Vote1: | 787,499 |
| Percentage1: | 51.91% |
| Nominee2: | Charles M. Hay |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 726,322 |
| Percentage2: | 47.88% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | James A. Reed |
| Before Party: | Democratic Party (US) |
| After Election: | Roscoe C. Patterson |
| After Party: | Republican Party (US) |
The 1928 United States Senate election in Missouri was held on November 6, 1928. Incumbent Democratic U.S. Senator James A. Reed did not run for re-election to a third term. Republican U.S. Representative Roscoe C. Patterson defeated Democrat Charles Hay to win the open seat.