| Election Name: | 1928 United States Senate election in Maine |
| Country: | Maine |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1922 United States Senate election in Maine |
| Previous Year: | 1922 |
| Next Election: | 1934 United States Senate election in Maine |
| Next Year: | 1934 |
| Election Date: | September 10, 1928 |
| Image1: | File:Frederickhale.jpg |
| Nominee1: | Frederick Hale |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 145,501 |
| Percentage1: | 69.64% |
| Nominee2: | Herbert E. Holmes |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 63,429 |
| Percentage2: | 30.36% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | Frederick Hale |
| Before Party: | Republican Party (US) |
| After Election: | Frederick Hale |
| After Party: | Republican Party (US) |
The 1928 United States Senate election in Maine was held on September 10, 1928.
Incumbent Republican Senator Frederick Hale was re-elected to a third term in office, defeating Governor Owen Brewster in the primary. Hale won the general election in a landslide.
Holmes was unopposed in the Democratic primary.