| Year: | 1927 |
| Team: | Millsaps Majors |
| Sport: | football |
| Conference: | Southern Intercollegiate Athletic Association |
| Short Conf: | SIAA |
| Record: | 3–8 |
| Conf Record: | 1–5 |
| Head Coach: | Herman F. Zimoski |
| Hc Year: | 6th |
The 1927 Millsaps Majors football team was an American football team that represented Millsaps College as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1927 college football season. In their sixth year under head coach Herman F. Zimoski, the team compiled a 3–8 record.