| 1927 Milan–San Remo | |
| Date: | 3 April |
| Stages: | 1 |
| Distance: | 285.5 |
| Unit: | km |
| Time: | 9h 43' 00" |
| Speed: | 29.485 |
| First: | Pietro Chesi |
| First Nat: | Italy |
| Second: | Alfredo Binda |
| Second Nat: | Italy |
| Third: | Domenico Piemontesi |
| Third Nat: | Italy |
| Previous: | 1926 |
| Next: | 1928 |
The 1927 Milan–San Remo was the 20th edition of the Milan–San Remo. The winner was Pietro Chesi (Italy).