| Election Name: | 1927 Combined Scottish Universities by-election |
| Type: | parliamentary |
| Country: | United Kingdom |
| Ongoing: | no |
| Previous Election: | 1924 United Kingdom general election |
| Previous Year: | 1924 |
| Next Election: | 1929 United Kingdom general election |
| Next Year: | 1929 |
| Election Date: | 26–29 April 1927 |
| Candidate1: | John Buchan |
| Party1: | Unionist Party (Scotland) |
| Popular Vote1: | 16,963 |
| Percentage1: | 87.7% |
| Party2: | Labour Party (UK) |
| Popular Vote2: | 2,378 |
| Percentage2: | 12.3% |
| MP | |
| Posttitle: | Subsequent MP |
| Before Party: | Unionist Party (Scotland) |
| After Party: | Unionist Party (Scotland) |
| Turnout: | 55.1% |
The 1927 Combined Scottish Universities by-election was a by-election held from 26 to 29 April 1927 for the Combined Scottish Universities, a university constituency of the British House of Commons.
The seat had become vacant on 16 March 1927 when the Unionist Member of Parliament (MP) Sir Henry Craik, Bt. had died, aged 80. He had held the seat since its creation for the 1918 general election, having previously been MP for Glasgow and Aberdeen Universities.
Two candidates contested the by-election. John Buchan, the novelist, of the Unionist Party and Hugh Guthrie of the Labour Party, who had contested Glasgow Camlachie at the 1918 general election.
The result was a victory for Buchan, who won nearly 88% of the votes. He held the seat until 1935, when he resigned to take up the post of Governor General of Canada.