| Year: | 1927 |
| Team: | Birmingham–Southern Panthers |
| Sport: | football |
| Conference: | Southern Intercollegiate Athletic Association |
| Short Conf: | SIAA |
| Record: | 3–6 |
| Conf Record: | 2–4 |
| Head Coach: | Harold Drew |
| Hc Year: | 4th |
| Stadium: | Rickwood Field |
The 1927 Birmingham–Southern Panthers football team was an American football team that represented Birmingham–Southern College as a member of the Southern Intercollegiate Athletic Association during the 1927 college football season. In their fourth season under head coach Harold Drew, the team compiled a 3–6 record.