| Election Name: | 1926 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1926 United States Senate special election in Missouri |
| Previous Year: | 1926 (special) |
| Next Election: | 1932 United States Senate election in Missouri |
| Next Year: | 1932 |
| Image1: | Harry Bartow Hawes.jpg |
| Nominee1: | Harry B. Hawes |
| Party1: | Democratic Party (US) |
| Popular Vote1: | 506,015 |
| Percentage1: | 51.30% |
| Nominee2: | George Howard Williams |
| Party2: | Republican Party (US) |
| Popular Vote2: | 470,654 |
| Percentage2: | 47.71% |
| Map Size: | 250px |
| U.S. senator | |
| Before Election: | George Howard Williams |
| Before Party: | Republican Party (US) |
| After Election: | Harry B. Hawes |
| After Party: | Democratic Party (US) |
The 1926 United States Senate election in Missouri took place on November 2, 1926 in Missouri. The Republican Senator elected in 1920, Selden P. Spencer, died on May 16, 1925. George Howard Williams was appointed to continue Spencer's term on May 25, and ran for a full term in this election. He was defeated by the Democratic nominee Harry B. Hawes, who won 51% of the vote. Hawes also defeated Williams in the special election held the same day.
The Prohibition Party nominated Herman P. Faris.