| Election Name: | 1922 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1916 United States Senate election in Wyoming |
| Previous Year: | 1916 |
| Next Election: | 1928 United States Senate election in Wyoming |
| Next Year: | 1928 |
| Election Date: | November 7, 1922 |
| Image1: | File:KENDRICK, JOHN B. GOVERNOR LCCN2016859134 (cropped).jpg |
| Nominee1: | John B. Kendrick |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 35,734 |
| Percentage1: | 57.30% |
| Nominee2: | Frank W. Mondell |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 26,627 |
| Percentage2: | 42.70% |
| Map Size: | 200px |
| U.S. Senator | |
| Before Election: | John B. Kendrick |
| Before Party: | Democratic Party (United States) |
| After Election: | John B. Kendrick |
| After Party: | Democratic Party (United States) |
The 1922 United States Senate election in Wyoming took place on November 7, 1922. First-term Democratic Senator John B. Kendrick ran for re-election to a second term. He was opposed by Republican Congressman Frank W. Mondell, the Majority Leader of the U.S. House of Representatives. Kendrick won re-election by a wide margin, defeating Mondell, despite his long record of representing the state in Congress, with 57% of the vote to Mondell's 43%. Kendrick was also able to increase his margin of victory from 1916, despite Republicans generally doing well in Wyoming in 1922.