| Election Name: | 1922 United States Senate election in Vermont |
| Country: | Vermont |
| Flag Year: | 1837 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1916 United States Senate election in Vermont |
| Previous Year: | 1916 |
| Next Election: | 1928 United States Senate election in Vermont |
| Next Year: | 1928 |
| Image1: | File:FrankLGreene.jpg |
| Nominee1: | Frank L. Greene |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 47,669 |
| Percentage1: | 69.04% |
| Party2: | Democratic Party (United States) |
| Nominee2: | William Mayo |
| Popular Vote2: | 21,375 |
| Percentage2: | 30.95% |
| Map Size: | 210px |
| U.S. Senator | |
| Before Election: | Carroll S. Page |
| Before Party: | Republican Party (United States) |
| After Election: | Frank L. Greene |
| After Party: | Republican Party (United States) |
The 1922 United States Senate election in Vermont took place on November 7, 1922. Incumbent Republican Carroll S. Page did not run for re-election to another term in the United States Senate. Republican candidate Frank L. Greene defeated Democratic candidate William B. Mayo to succeed him.