| Election Name: | 1922 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1916 United States Senate election in Missouri |
| Previous Year: | 1916 |
| Next Election: | 1928 United States Senate election in Missouri |
| Next Year: | 1928 |
| Election Date: | November 7, 1922 |
| Image1: | File:James A. Reed.jpg |
| Nominee1: | James A. Reed |
| Party1: | Democratic Party (US) |
| Popular Vote1: | 506,264 |
| Percentage1: | 51.85% |
| Nominee2: | R.R. Brewster |
| Party2: | Republican Party (US) |
| Popular Vote2: | 462,009 |
| Percentage2: | 47.32% |
| Map Size: | 270px |
| U.S. Senator | |
| Before Election: | James A. Reed |
| Before Party: | Democratic Party (US) |
| After Election: | James A. Reed |
| After Party: | Democratic Party (US) |
The 1922 United States Senate election in Missouri was held on November 7, 1922. Incumbent Democratic U.S. Senator James A. Reed was re-elected to a third term over Republican R. R. Brewster.