See main article: 1922 U.S. National Championships (tennis).
Two-time defending champion Bill Tilden defeated Bill Johnston in the final, 4–6, 3–6, 6–2, 6–3, 6–4 to win the men's singles tennis title at the 1922 U.S. National Championships.[1] It was Tilden's third U.S. Championships singles title and fifth major singles title overall.