| Team: | Rochester Jeffersons |
| Year: | 1922 |
| Record: | 0–4–1 |
| League Place: | T-15th in NFL |
| Coach: | Doc Alexander |
The 1922 Rochester Jeffersons season was their third in the league. The team failed to improve on their previous output of 2–3, going 0–4–1.[1] They tied for fifteenth place in the league.
| Week | Date | Opponent | Result | Record | Venue | Recap | |
|---|---|---|---|---|---|---|---|
| 1 | October 12 | at Akron Pros | T 13–13 | 0–0–1 | Elk's Field | Recap | |
| 2 | October 15 | at Chicago Bears | L 0–7 | 0–1–1 | Cubs Park | Recap | |
| 3 | October 22 | at Rock Island Independents | L 0–26 | 0–2–1 | Douglas Park | Recap | |
| 4 | October 29 | at Racine Legion | L 0–9 | 0–3–1 | Horlick Field | Recap | |
| 5 | November 30 | Buffalo All-Americans | L 0–21 | 0–4–1 | Edgerton Park | Recap |