| Election Name: | 1922 Manchester Clayton by-election |
| Type: | presidential |
| Country: | United Kingdom |
| Previous Election: | Manchester Clayton (UK Parliament constituency)#Elections in the 1910s |
| Previous Year: | 1918 |
| Next Election: | Manchester Clayton (UK Parliament constituency)#Elections in the 1920s |
| Next Year: | 1922 |
| Election Date: | 18 February 1922 |
| Candidate1: | Sutton |
| Party1: | Labour Party (UK) |
| Popular Vote1: | 14,662 |
| Percentage1: | 57.05% |
| Candidate2: | Flanagan |
| Party2: | Unionist Party (UK) |
| Popular Vote2: | 11,038 |
| Percentage2: | 42.94% |
| Map Size: | 250px |
| MP | |
| Posttitle: | Subsequent MP |
| Before Election: | Hopkinson |
| Before Party: | Unionist Party (UK) |
| After Election: | Sutton |
| After Party: | Labour Party (UK) |
The 1922 Manchester Clayton by-election of 18 February 1922 was held after the death of the Conservative politician and Member of Parliament (MP) Edward Hopkinson. Labour took the seat in the by-election.