| Year: | 1922 |
| Team: | Drexel Dragons |
| Sport: | football |
| Conference: | Independent |
| Record: | 2–4 |
| Head Coach: | Harry J. O'Brien |
| Hc Year: | 1st |
| Stadium: | Strawbridge & Clothier Field |
The 1922 Drexel Dragons football team represented Drexel Institute—now known as Drexel University—in the 1922 college football season. Led by Harry J. O'Brien in his first season as head coach, the team compiled a record of 2–4.