The 1922 Columbus Panhandles season was their third in the league and last season as the Panhandles. The team failed to improve on their previous output of 1–8, losing all their games.[1] They tied for fifteenth place in the league.
| Week | Date | Opponent | Result | Record | |
|---|---|---|---|---|---|
| 1 | October 1 | at Akron Pros | L 0–36 | 0–1 | |
| 2 | October 8 | at Oorang Indians | L 6–20 | 0–2 | |
| 3 | October 15 | at Buffalo All-Americans | L 0–19 | 0–3 | |
| 4 | October 29 | at Chicago Cardinals | L 6–37 | 0–4 | |
| 5 | November 5 | at Green Bay Packers | L 0–3 | 0–5 | |
| 6 | November 11 | at Racine Legion | L 0–34 | 0–6 | |
| 7 | November 26 | at Toledo Maroons | L 6–7 | 0–7 | |
| 8 | November 30 | Oorang Indians | L 6–18 | 0–8 |