| Election Name: | 1922 City of London by-election |
| Popular Vote2: | 6,178 |
| Turnout: | 36.96% |
| After Party: | Unionist Party (UK) |
| After Election: | Edward Grenfell |
| Before Party: | Unionist Party (UK) |
| Before Election: | Arthur Balfour |
| Posttitle: | Subsequent MP |
| MP | |
| Percentage2: | 37.92% |
| Party2: | Independent Unionist |
| Type: | parliamentary |
| Candidate2: | Vansittart Bowater |
| Percentage1: | 62.08% |
| Popular Vote1: | 10,114 |
| Party1: | Unionist Party (UK) |
| Image1: | UP |
| Candidate1: | Edward Grenfell |
| Election Date: | 19 May 1922 |
| Next Year: | 1922 (GE) |
| Next Election: | 1922 United Kingdom general election |
| Previous Year: | 1918 |
| Previous Election: | 1918 United Kingdom general election |
| Country: | United Kingdom |
| Seats For Election: | Constituency of City of London |
The 1922 City of London by-election was a parliamentary by-election held on 19 May 1922 for the British House of Commons constituency of City of London, which covered the "Square Mile" which was the United Kingdom's traditional financial district.
The seat had become vacant on the elevation to the peerage of one of the constituency's two Unionist Members of Parliament (MPs), Arthur James Balfour, as the Earl of Balfour.
Balfour had held the seat since a by-election in 1906, following his defeat at Manchester East in the 1906 general election. He had also been prime minister between 1902 and 1905.
The Unionist Party selected as its candidate Edward Grenfell, who was a director of the Bank of England. Sir Vansittart Bowater, who had been Lord Mayor of London in 1913, stood as an Independent Unionist.
Turnout was unsurprisingly low in the first contested election in the City since the first 1910 general election. Grenfell won the seat by a convincing margin.
Curiously, Bowater would go on to be elected as the official Unionist candidate at a by-election in 1924, and he and Grenfell would share the representation of the City until 1935.