Western Canada Rugby Football Union joined the CRU and challenged for the Grey Cup. The Edmonton Eskimos became the first Western team to play in a Grey Cup game, but lost to the Toronto Argonauts 23–0.
Rule changes included reducing players from 14 to 12 per side; putting ball into play by snapping it back; limit of 18 players with substitutes permitted freely.
Note: GP = Games Played, W = Wins, L = Losses, T = Ties, PF = Points For, PA = Points Against, Pts = Points
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| Winnipeg Victorias | 4 | 4 | 0 | 0 | 59 | 37 | 8 |
| 4 | 2 | 2 | 0 | 53 | 41 | 4 | |
| University of Manitoba Varsity | 4 | 0 | 4 | 0 | 53 | 87 | 0 |
| Southern Saskatchewan | ||||||||
| Regina Rugby Club | 4 | 4 | 0 | 0 | 86 | 11 | 8 | |
| Regina Boat Club | 4 | 2 | 2 | 0 | 34 | 28 | 4 | |
| Moose Jaw Millers | 4 | 0 | 4 | 0 | 12 | 93 | 0 | |
| Northern Saskatchewan | ||||||||
| Saskatoon Quakers | 3 | 2 | 1 | 0 | 43 | 18 | 4 | |
| University of Saskatchewan Varsity | 3 | 1 | 2 | 0 | 18 | 43 | 2 | |
| Edmonton Eskimos | 3 | 3 | 0 | 0 | 148 | 5 | 6 | |
| University of Alberta Varsity | 4 | 1 | 3 | 0 | 35 | 113 | 2 | |
| Calgary Rugby Club | 3 | 1 | 2 | 0 | 39 | 104 | 2 |
| IRFU | Toronto Argonauts | |
| WCRFU | Edmonton Eskimos | |
| CIRFU | University of Toronto | |
| ORFU | Toronto Parkdale | |
| MRFU | Winnipeg Victorias | |
| SRFU | Saskatoon Quakers[3] | |
| ARFU | Edmonton Eskimos |
Note: All dates in 1921
| December 39th Annual Grey Cup Game | ||
|---|---|---|
| Edmonton Eskimos 0 | Toronto Argonauts 23 | |
| Toronto Argonauts are the 1921 Grey Cup Champions | ||
NOTE: During this time most players played both ways, so the All-Star selections do not distinguish between some offensive and defensive positions.