| Year: | 1921 |
| Team: | VMI Keydets |
| Sport: | football |
| Conference: | South Atlantic Intercollegiate Athletic Association |
| Short Conf: | SAIAA |
| Record: | 3–5–1 |
| Conf Record: | 0–3–1 |
| Head Coach: | Blandy Clarkson |
| Hc Year: | 2nd |
| Stadium: | Alumni Field |
The 1921 VMI Keydets football team was an American football team that represented the Virginia Military Institute (VMI) during the 1921 college football season as a member of the South Atlantic Intercollegiate Athletic Association. In their second year under head coach Blandy Clarkson, the team compiled an overall record of 3–5–1.[1]