| Team: | Tonawanda Kardex |
| Year: | 1921 |
| Record: | 0–1–1 overall 0–1 in APFA |
| League Place: | T-18th in APFA |
| Coach: | Tam Rose |
| Stadium: | Traveling team |
| Previous: | none |
| No Prevseason: | true |
| Next: | none |
| No Nextseason: | true |
| No Seasonslist: | true |
The 1921 Tonawanda Kardex season was their sole season in the young American Professional Football Association (APFA), in which they played only one game. The team finished 0–1 in league play,[1] and tied for eighteenth place in the league.
| Week | Date | Opponent | Result | |
|---|---|---|---|---|
| – | October 9 | at Syracuse Pros | T 0–0 | |
| – | October 30 | at Rochester Scalpers | Cancelled[2] | |
| 1 | November 6 | at Rochester Jeffersons | L 0–45 |