| Year: | 1921 |
| Team: | South Carolina Gamecocks |
| Sport: | football |
| Conference: | Southern Intercollegiate Athletic Association |
| Short Conf: | SIAA |
| Record: | 5–1–2 |
| Conf Record: | 2–1–1 |
| Head Coach: | Sol Metzger |
| Hc Year: | 2nd |
| Captain: | Tatum Gressette |
| Stadium: | University Field |
The 1921 South Carolina Gamecocks football team represented the University of South Carolina during the 1921 Southern Intercollegiate Athletic Association football season. Led by second-year head coach Sol Metzger, the Gamecocks compiled an overall record of record of 5–1–2 with a mark of 2–1–1 in SIAA play.